Indole-3-carbinol (I3C) is a phytochemical derived in high concentrations from the Brassica family of vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. I3C and its derivative compounds have been shown to exert immunomodulatory effects in the human body. I3C has been shown to exhibit direct antiestrogenic activity via competitive inhibition of estrogen receptors, upregulate the cytochrome P450 isoenzymes CYP1A1, CYP1A2, and CYP1B1, thereby increasing estrogen metabolism, and shift estrogen metabolism away from the more proliferative (16‑OHE₁) towards the more protective (2‑OHE₁) estrogen species.

At Five Natural, we do our best to ensure accuracy and up to date product information and product images on our website. Please note that occasionally manufacturing changes to packaging or ingredients may be pending updates on our website.

On occasion, products may ship with different packaging as per recent updates by the manufacturer or supplier. In these instances, although ingredients often remain the same with the exception of updated packaging we strongly recommend that you read all associated labels, warnings and directions before use. Do not rely solely on the information provided on Five Natural's website.

Probiotics are kept refrigerated in our warehouse. Probiotics will ship with a free ice pack. The product may not be cold upon delivery but the ice pack helps maintain a cool temperature throughout transit, consider weekend delays when ordering.

Contains no: Gluten, soy, wheat, corn, dairy, yeast, preservatives, artificial flavour or colour, sugar, or starch.